Interindividual and topographical variation of L:M cone ratios in monkey retinas

Samir S. Deeb; Lisa C. Diller; David R. Williams; Dennis M. Dacey

doi:10.1364/JOSAA.17.000538

Journal of the Optical Society of America A
Vol. 17,
Issue 3,
pp. 538-544
(2000)
•https://doi.org/10.1364/JOSAA.17.000538

Interindividual and topographical variation of L:M cone ratios in monkey retinas

Samir S. Deeb, Lisa C. Diller, David R. Williams, and Dennis M. Dacey

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Samir S. Deeb, Lisa C. Diller, David R. Williams, and Dennis M. Dacey, "Interindividual and topographical variation of L:M cone ratios in monkey retinas," J. Opt. Soc. Am. A 17, 538-544 (2000)

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Abstract

We analyzed the ratio of L:M cone photopigment mRNA in the retinas of Old World monkeys, using the method of rapid polymerase chain reaction–single-strand conformation polymorphism. The L:M cone pigment mRNA ratio in whole retina ranged from 0.6 to 7.0, with a mean of ∼1.6 (standard deviation, ±0.56; $n = 26) .$ There was no change in this ratio with eccentricity up to 9 mm (∼45°), though the ratio was ∼30% greater in temporal than in nasal retina. The mRNA ratios are in good agreement with the L:M cone ratio in these same retinas, inferred from electrophysiological recordings of cone signal gain in horizontal cell interneurons. The correlation between mRNA ratios and physiological cone gain ratio supports the conclusion that both measures reflect the relative number of L and M cones.

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			Monkey Identification Number
Properties	89251	96111	95265	87264	91048	88105
Properties	89251	96111	95265	87264	91048	Left Eye	Right Eye
Species	M. nemestrina	M. nemestrina	M. nemestrina	M. nemestrina	M. fascicularis	M. fascicularis	M. fascicularis
Sex	Female	Female	Male	Female	Female	Female	Female
Section
Superior-1	$2.23 \pm 0.02$	$1.58 \pm 0.26$	$1.13 \pm 0.16$	2.66±0.12	$1.73 \pm 0.36$	$1.98 \pm 0.22$	ND
Superior-2	$1.98 \pm 0.15$	$1.03 \pm 0.21$	$1.33 \pm 0.32$	$3.35 \pm 0.19$	$1.41 \pm 0.14$	$2.33 \pm 0.25$	ND
Superior-3	$2.00 \pm 0.63$	$0.95 \pm 0.26$	$1.78 \pm 0.31$	ND	$2.24 \pm 0.12$	ND	ND
Inferior-1	$1.98 \pm 0.16$	$0.97 \pm 0.21$	$1.56 \pm 0.25$	$2.41 \pm 0.12$	$1.63 \pm 0.14$	$2.35 \pm 0.17$	ND
Inferior-2	$1.95 \pm 0.38$	$0.71 \pm 0.23$	$1.57 \pm 0.21$	$2.56 \pm 0.06$	$1.39 \pm 0.14$	$2.32 \pm 0.10$	ND
Inferior-3	$1.76 \pm 0.02$	ND	ND	ND	$1.54 \pm 0.72$	ND	ND
Nasal-1	$1.29 \pm 0.11$	$0.86 \pm 0.04$	$1.57 \pm 0.20$	$2.77 \pm 0.55$	$1.42 \pm 0.14$	$1.52 \pm 0.11$	$2.26 \pm 0.13$
Nasal-2	$1.17 \pm 0.01$	$0.63 \pm 0.02$	$1.16 \pm 0.12$	$2.21 \pm 0.25$	$1.34 \pm 0.16$	$1.52 \pm 0.27$	$2.21 \pm 0.19$
Nasal-3	$1.22 \pm 0.12$	$0.76 \pm 0.11$	$1.09 \pm 0.03$	$1.92 \pm 0.10$	ND	$1.12 \pm 0.18$	$3.21 \pm 0.11$
Nasal-4	ND	ND	$1.30 \pm 0.12$	ND	ND	ND	$3.07 \pm 0.32$
Temporal-1	$2.65 \pm 0.08$	ND	$2.15 \pm 0.26$	$3.13 \pm 0.22$	$1.81 \pm 0.19$	$2.16 \pm 0.10$	$2.90 \pm 0.18$
Temporal-2	$2.48 \pm 0.45$	ND	$1.98 \pm 0.23$	$3.39 \pm 0.34$	$1.77 \pm 0.21$	$2.31 \pm 0.22$	$3.02 \pm 0.17$
Temporal-3	$2.56 \pm 0.33$	$1.48 \pm 0.23$	ND	ND	$1.61 \pm 0.09$	ND	$3.18 \pm 0.15$
Fovea	$2.62 \pm 0.20$	$1.23 \pm 0.27$	$2.04 \pm 0.34$	$3.13 \pm 0.20$	$1.81 \pm 0.12$	$1.55 \pm 0.09$	$2.27 \pm 0.14$
Remainder	$2.49 \pm 0.08$	$0.93 \pm 0.25$	$1.35 \pm 0.34$	$2.85 \pm 0.33$	$1.52 \pm 0.09$	ND	ND

	Monkey Identification Number
	$J 91076$	$J 9026$	88296
Sex	Male	Male	Female
Axis
L-superior	$1.15 \pm 0.24$	$2.20 \pm 0.24$	$0.86 \pm 0.09$
L-temporal	$1.71 \pm 0.04$	$2.38 \pm 0.45$	$1.11 \pm 0.07$
L-temporal	$1.85 \pm 0.08$	$2.78 \pm 0.27$	ND
L-nasal	$1.32 \pm 0.01$	$1.96 \pm 0.05$	$0.70 \pm 0.06$
L-nasal	ND	$2.74 \pm 0.16$	ND
L-inferior	ND	ND	$0.72 \pm 0.09$
Remainder	ND	$2.28 \pm 0.68$	ND

			Monkey Identification Number
Properties	89251	96111	95265	87264	91048	88105
Properties	89251	96111	95265	87264	91048	Left Eye	Right Eye
Species	M. nemestrina	M. nemestrina	M. nemestrina	M. nemestrina	M. fascicularis	M. fascicularis	M. fascicularis
Sex	Female	Female	Male	Female	Female	Female	Female
Section
Superior-1	$2.23 \pm 0.02$	$1.58 \pm 0.26$	$1.13 \pm 0.16$	2.66±0.12	$1.73 \pm 0.36$	$1.98 \pm 0.22$	ND
Superior-2	$1.98 \pm 0.15$	$1.03 \pm 0.21$	$1.33 \pm 0.32$	$3.35 \pm 0.19$	$1.41 \pm 0.14$	$2.33 \pm 0.25$	ND
Superior-3	$2.00 \pm 0.63$	$0.95 \pm 0.26$	$1.78 \pm 0.31$	ND	$2.24 \pm 0.12$	ND	ND
Inferior-1	$1.98 \pm 0.16$	$0.97 \pm 0.21$	$1.56 \pm 0.25$	$2.41 \pm 0.12$	$1.63 \pm 0.14$	$2.35 \pm 0.17$	ND
Inferior-2	$1.95 \pm 0.38$	$0.71 \pm 0.23$	$1.57 \pm 0.21$	$2.56 \pm 0.06$	$1.39 \pm 0.14$	$2.32 \pm 0.10$	ND
Inferior-3	$1.76 \pm 0.02$	ND	ND	ND	$1.54 \pm 0.72$	ND	ND
Nasal-1	$1.29 \pm 0.11$	$0.86 \pm 0.04$	$1.57 \pm 0.20$	$2.77 \pm 0.55$	$1.42 \pm 0.14$	$1.52 \pm 0.11$	$2.26 \pm 0.13$
Nasal-2	$1.17 \pm 0.01$	$0.63 \pm 0.02$	$1.16 \pm 0.12$	$2.21 \pm 0.25$	$1.34 \pm 0.16$	$1.52 \pm 0.27$	$2.21 \pm 0.19$
Nasal-3	$1.22 \pm 0.12$	$0.76 \pm 0.11$	$1.09 \pm 0.03$	$1.92 \pm 0.10$	ND	$1.12 \pm 0.18$	$3.21 \pm 0.11$
Nasal-4	ND	ND	$1.30 \pm 0.12$	ND	ND	ND	$3.07 \pm 0.32$
Temporal-1	$2.65 \pm 0.08$	ND	$2.15 \pm 0.26$	$3.13 \pm 0.22$	$1.81 \pm 0.19$	$2.16 \pm 0.10$	$2.90 \pm 0.18$
Temporal-2	$2.48 \pm 0.45$	ND	$1.98 \pm 0.23$	$3.39 \pm 0.34$	$1.77 \pm 0.21$	$2.31 \pm 0.22$	$3.02 \pm 0.17$
Temporal-3	$2.56 \pm 0.33$	$1.48 \pm 0.23$	ND	ND	$1.61 \pm 0.09$	ND	$3.18 \pm 0.15$
Fovea	$2.62 \pm 0.20$	$1.23 \pm 0.27$	$2.04 \pm 0.34$	$3.13 \pm 0.20$	$1.81 \pm 0.12$	$1.55 \pm 0.09$	$2.27 \pm 0.14$
Remainder	$2.49 \pm 0.08$	$0.93 \pm 0.25$	$1.35 \pm 0.34$	$2.85 \pm 0.33$	$1.52 \pm 0.09$	ND	ND

	Monkey Identification Number
	$J 91076$	$J 9026$	88296
Sex	Male	Male	Female
Axis
L-superior	$1.15 \pm 0.24$	$2.20 \pm 0.24$	$0.86 \pm 0.09$
L-temporal	$1.71 \pm 0.04$	$2.38 \pm 0.45$	$1.11 \pm 0.07$
L-temporal	$1.85 \pm 0.08$	$2.78 \pm 0.27$	ND
L-nasal	$1.32 \pm 0.01$	$1.96 \pm 0.05$	$0.70 \pm 0.06$
L-nasal	ND	$2.74 \pm 0.16$	ND
L-inferior	ND	ND	$0.72 \pm 0.09$
Remainder	ND	$2.28 \pm 0.68$	ND

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Journal of the Optical Society of America A